The UEFA Europa League has undergone a dramatic transformation this season, and the excitement is building as we approach the round-of-16 stage. With a revamped league phase that has already delivered surprises and standout performances, the knockout rounds promise even more drama. Whether you’re a die-hard fan tracking every tactical nuance or a casual viewer drawn in by the spectacle, this guide from Mostplay breaks down the draw process, potential matchups, and key dates you need to mark on your calendar.
When Does the Round of 16 Draw Take Place?
The official draw for the Europa League round of 16 is scheduled for February 21 at 7 a.m. ET / midday GMT. This event will determine the fixtures that will shape the next phase of the competition. The exact dates and times for each specific tie will be announced later that same day, so fans should stay tuned for updates as the bracket takes shape.
Which Clubs Are Already in the Round of 16?
The top eight finishers from the league phase earned automatic spots in the round of 16, bypassing the knockout playoff round. These elite clubs are joined by eight teams that advanced through the playoffs, creating a diverse and competitive field. Here’s the full list of participants:
- Ajax Amsterdam(Knockout Playoff Winner)
- AS Roma(Knockout Playoff Winner)
- Athletic Club
- AZ Alkmaar(Knockout Playoff Winner)
- Bodo/Glimt(Knockout Playoff Winner)
- Eintracht Frankfurt
- FCSB(Knockout Playoff Winner)
- Fenerbahce(Knockout Playoff Winner)
- Lazio
- Lyon
- Manchester United
- Olympiacos
- Rangers
- Real Sociedad
- Tottenham Hotspur
- Viktoria Plzen(Knockout Playoff Winner)
Clubs that finished between 25th and 36th in the league phase have been eliminated, making this a high-stakes round for the remaining contenders.

How Does the New Round of 16 Draw Work?
The UEFA Europa League’s new format introduces a unique approach to the draw, moving away from the traditional random pairing. Instead, the knockout bracket is largely predetermined based on each club’s final position in the league table. For example, Manchester United (who finished third) and Tottenham Hotspur (fourth) can only face teams placed 13th, 14th, 19th, or 20th—specifically Real Sociedad, Galatasaray, AZ Alkmaar, or FC Midtjylland.
Under this system, the draw places teams into specific positions in the bracket to create fixtures, rather than randomly selecting opponents. The top eight teams are grouped into pairs: 1st and 2nd, 3rd and 4th, 5th and 6th, and 7th and 8th. These pairs are drawn into opposite halves of the bracket, meaning they cannot meet until the final. The process begins with the 7th and 8th pair (Lyon and Olympiacos) and works upward through the other pairs: Eintracht Frankfurt and Lyon, Manchester United and Tottenham, and finally Lazio and Athletic Club.
As an example, Manchester United and Tottenham have two possible opponents: AZ Alkmaar (who defeated Galatasaray in the playoffs) and Real Sociedad (who knocked out FC Midtjylland). The first team drawn from this pair will enter the top half of the bracket and face AZ Alkmaar, while the other automatically moves to the bottom half against Real Sociedad.

How Is the Bracket Shaping Up?
The second half of the bracket, which includes Roma and Real Sociedad, appears to be the more challenging path based on the placement of knockout playoff round teams. This means clubs in the round of 16 draw will likely prefer to be drawn first and land in the top half. The full bracket through to the final is now set, with no additional draws needed for the quarterfinals or semifinals—those ties are already determined by the initial positioning.
Possible Round of 16 Ties
Based on the league phase standings and playoff results, here are the potential matchups we could see in the round of 16:
- Viktoria Plzen or AS Roma vs. Athletic Club
- Viktoria Plzen or AS Roma vs. Lazio
- Real Sociedad or AZ Alkmaar vs. Manchester United
- Real Sociedad or AZ Alkmaar vs. Tottenham Hotspur
- Ajax Amsterdam or FCSB vs. Eintracht Frankfurt
- Ajax Amsterdam or FCSB vs. Lyon
- Fenerbahce or Bodo/Glimt vs. Olympiacos
- Fenerbahce or Bodo/Glimt vs. Rangers
Teams that finished in the top eight are seeded and will enjoy home advantage in the second leg. This adds a strategic layer, as clubs will aim to secure strong results in the first leg to leverage their home crowd.
Is There Country Protection in the Draw?
No, country protection does not apply from the knockout playoff round onward. This means clubs from the same nation can face each other. For instance, Lazio and Roma could be drawn together, setting up a thrilling Rome derby in the round of 16—a scenario that would undoubtedly electrify fans and add an extra layer of intensity to the competition.
Key Dates for the Knockout Stages
The round of 16 will take place across two legs, with the first legs scheduled for March 6 and the second legs on March 13. Each club will play once on a Tuesday and once on a Wednesday. Beyond the round of 16, the remaining knockout dates are as follows:
- Quarterfinals: First legs on April 10, second legs on April 17
- Semifinals: First legs on May 1, second legs on May 8
- Final: May 21 at San Mamés Stadium, Bilbao
Who Gets Home Advantage in the Quarterfinals and Semifinals?
A separate draw will take place immediately after the round of 16 is finalized on February 21 to determine which club plays at home first in the quarterfinals and semifinals. Unlike the round of 16, this is not based on league-phase seeding, so no team has a predetermined home advantage beyond the initial stage.
Can January Signings Play in the Europa League?
Yes, clubs are allowed to make up to three changes to their official squad for the knockout rounds. This means new signings from the January transfer window can be registered, but there’s a catch: if a club signed more than three players, they would have to leave some out. The overall squad limit of 25 players remains, so any addition requires removing an existing player from the roster. This rule adds a strategic dimension for managers as they balance squad depth with tactical needs.
Final Thoughts
The Europa League’s new format has already delivered a fresh dynamic, and the round of 16 draw on February 21 will set the stage for what promises to be an unforgettable knockout phase. From potential all-Italian clashes like Roma vs. Lazio to heavyweight encounters involving Manchester United and Tottenham, the bracket is packed with intrigue. As a fan, staying informed about these developments is key—Mostplay is your go-to source for the latest insights and analysis. What are your predictions for the round of 16? Share your thoughts in the comments below, and don’t forget to explore more content on our site for in-depth coverage of all the action.
